Cardiogen (AEDL Peptide, Ala-Glu-Asp-Leu) is a 4-amino-acid synthetic myocardium bioregulator peptide from Khavinson's cytomedine program, specifically targeting heart muscle tissue. As a tissue-specific bioregulator, AEDL regulates gene expression in cardiomyocytes at ∼10^-12 M concentrations via epigenetic mechanisms, promoting cardiomyocyte proliferation and survival rather than hypertrophy. Preclinical studies show Cardiogen stimulates proliferation of existing cardiomyocytes in young and old rat myocardial cultures and improves contractile function. It is the most specific peptide for myocardial regeneration research, age-related cardiac decline models, cardiomyocyte proliferation and anti-apoptosis studies, and cardiovascular bioregulator stacks.
Cardiogen restores myocardium via three integrated actions. 1. AEDL Peptide: Synthetic tetrapeptide Ala-Glu-Asp-Leu, cell-penetrating targets cardiomyocyte membrane receptors, initiates intracellular signaling cascades, low concentration high bioactivity ∼10^-12 M. 2. Cardiomyocyte Proliferation & Survival: Cardiogen AEDL PI3K/Akt Pathway Activation → Akt phosphorylated → mTOR activation ↑ → Cyclin D1, Ki67 upregulated → Stimulates Cardiomyocyte Proliferation ↑. Apoptosis Inhibition: Downregulates p53 expression → reduces programmed cell death → increases cell survival. 3. Myocardium Repair & Cardiovascular Bioregulation: Tissue Repair & Remodeling: Reduces fibrosis & scar tissue, promotes ECM remodeling. Angiogenesis & Vascularization: VEGF signaling ↑ → new capillary formation, improved blood flow & oxygen delivery. Bioregulation & Cardioprotection: Anti-inflammatory ↓IL-6 ↓TNF-α, reduces oxidative stress & ROS, restores Ca2+ homeostasis & contractile function. Key Outcomes: ↑Cardiomyocyte Proliferation, ↗️Myocardial Repair & Angiogenesis, ↓Improved Cardiac Function. Overall Effect: Restores myocardium after injury by increasing healthy cardiomyocyte numbers, reducing fibrosis, enhancing vascular growth, and regulating inflammatory and apoptotic pathways. Preclinical evidence: stimulates proliferation of existing cardiomyocytes, suppresses p53-mediated apoptosis, supports myocardial repair.
Our Cardiogen lineup is supplied as high-purity lyophilized powder (>98% HPLC) with COA. For myocardium bioregulator research, Cardiogen 10mg (AEDL – standard and most requested) and 20mg (value) are available, typically used in 10-20 day bioregulator cycles. Cardiogen belongs to Repair & Anti-Aging Peptides category, Cardiovascular Bioregulator sub-group, alongside Vesugen (KED - vessels) and Crystagen (AEDG). Commonly stacked with Vesugen + Crystagen for comprehensive cardiovascular + immune repair protocol. Stable 24 months at -20°C. For Research Use Only, not for human consumption.