Reproductive & Immune Peptides are a specialized dual-axis category targeting hormonal reproduction and adaptive immunity. This category is designed for four key research areas: individuals and couples studying fertility and HPG axis dysfunction, protocols focused on hypoactive sexual desire disorder (HSDD) and libido, researchers studying immune deficiency, frequent infections and post-viral immune recovery, and labs investigating the crosstalk between sex hormones and immune function. By acting on central hypothalamic pathways and thymic T-cell maturation, these peptides regulate reproduction and defense at the upstream level.
This class works through two central mechanisms. First, the Hypothalamic-Pituitary-Gonadal (HPG) axis: Kisspeptin 1mg, 5mg, 10mg (KISS1) binds to KISS1R (GPCR) on GnRH neurons in the hypothalamus, increasing intracellular Ca2+ and triggering pulsatile GnRH release, which then stimulates LH & FSH secretion from the pituitary to drive testosterone, estrogen, spermatogenesis and oogenesis. Gonadorelin 2mg is a direct GnRH analog for the same pathway, while HCG 5000IU mimics LH to support gonadal function. Second, central melanocortin arousal: PT-141 2mg and 10mg (Bremelanotide) is a synthetic MC4R/MC3R agonist acting in the paraventricular nucleus of the hypothalamus to increase dopamine and oxytocin release, promoting sexual response and arousal without acting on the vascular system. For immunity, Thymosin Alpha-1 5mg and 10mg (Ta1, 28-AA thymus-derived peptide) binds to TLR receptors on immune cells, enhances T-cell maturation, promotes Th1 response, and increases CD4+ T-helper differentiation, CD8+ cytotoxic activity, and NK cell activity. Oxytocin 2mg and 5mg further supports bonding, stress reduction and immune modulation. Cross-talk: estrogen enhances antibody response while testosterone is immunosuppressive, and Kisspeptin also expresses KISS1R on immune cells to link reproduction and inflammation.
Our complete Reproductive & Immune lineup is supplied as high-purity lyophilized powder (>99% HPLC). For HPG activation and fertility research, Kisspeptin-10 1mg, 5mg and 10mg, Kisspeptin-54 and Gonadorelin 2mg are the core GnRH pathway models. For sexual wellness research, PT-141 2mg (standard) and 10mg (high-dose), PT-141 + Oxytocin Blend 5mg are the most requested melanocortin agonists for non-hormonal central arousal. For immune modulation, Thymosin Alpha-1 5mg and 10mg is the gold standard for T-cell immunity and is widely used as an immunoadjuvant in infection and oncology research. For gonadal and hormonal support, HCG 5000IU Lyophilized and Oxytocin 2mg and 5mg complete the reproductive axis toolkit. For synergistic protocols, Kisspeptin + Gonadorelin Blend and Thymosin Alpha-1 + Thymosin Beta-4 Blend are available. All vials include COA, stored at 2-8°C. For Research Use Only.