5-Amino-1MQ (5-Amino-1-Methylquinolinium, C10H11N2+) is a selective small-molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), a key metabolic enzyme overexpressed in adipose and aged muscle. NNMT drains NAM into 1-MNA waste, depleting NAD+ and SAM. 5-Amino-1MQ blocks this drain to restore NAD+ and preserve methylation capacity. Unlike GLP-1 agonists that suppress appetite, 5-Amino-1MQ increases metabolic rate at the cellular level, promotes lean phenotype without muscle loss. It is the top trending compound for fat loss while preserving lean muscle during cutting, metabolic syndrome and insulin resistance research, NAD+ salvage and sirtuin activation studies, and muscle regeneration and mitochondrial function.
5-Amino-1MQ restores metabolism via four interlocked pathways. 1. THE PROBLEM – NNMT DRAIN: NNMT converts Nicotinamide (NAM) → 1-Methylnicotinamide (1-MNA) metabolic drain, causes reduced SIRT activity, ↓mitochondrial function, SAM depleted for methylation, ↑fat storage in adipose, ↓muscle regeneration. 2. INTERVENTION: 5-Amino-1MQ blocks NNMT active site, inhibits NNMT → prevents NAM methylation → preserves NAM pool and SAM levels, redirects flux to NAD+ salvage. 3. NAD+ SALVAGE RESTORED: NAM → NAMPT → NMN (Nicotinamide Mononucleotide) → NAD+ biosynthesis. NAD+ ↑ → activates downstream SIRT1 deacetylase activity ↑, PGC-1α ↑ → OXPHOS production → cellular resilience & repair. NAD+ is cofactor for sirtuins, fueling healthy aging & metabolism. 4. METABOLIC OUTCOMES: Muscle Metabolism: ↑muscle regeneration & repair, ↑mitochondrial function in skeletal muscle, improved muscle mass & endurance. Adipose/Fat Metabolism: ↓lipogenesis/fat storage, ↑fatty acid oxidation (β-oxidation), leaner phenotype – reduced fat mass. SAM Cycle Impact: Preserved SAM supports DNA/histone methylation & epigenetic health (SAM → SAH → Homocysteine → Methionine → back to SAM).
Our 5-Amino-1MQ lineup is supplied as high-purity powder (>99% HPLC) with COA. For oral and injectable research, we offer 5-Amino-1MQ 50mg (standard - most requested), 5-Amino-1MQ 100mg (high-dose), 5-Amino-1MQ 150mg (value bulk) vials, and 5-Amino-1MQ Capsules 50mg x 60 and 100mg x 60 for daily dosing models. 5-Amino-1MQ belongs to Fat Metabolism Peptides category but uniquely acts via NNMT inhibition, not via GLP-1 or lipolysis directly. Commonly stacked with SLU-PP-332 (ERRα mitochondrial biogenesis) and MOTS-c 5mg (mitochondrial peptide) for comprehensive NAD+/mitochondria/fat oxidation protocol. Stable 24 months at -20°C. For Research Use Only, not for human consumption.