CJC-1295 No DAC 5mg + Ipamorelin 5mg Blend (10mg total) is the best-selling and most researched growth hormone peptide blend, combining 5mg Modified GRF 1-29 (CJC-1295 without DAC) and 5mg Ipamorelin in a single vial for synergistic GH release. This 1:1 ratio provides equal potency from both pathways: GHRH axis (CJC No DAC) and GHRP axis (Ipamorelin). The blend solves the limitation of single-pathway stimulation: CJC No DAC alone increases pulse frequency, Ipamorelin alone increases pulse amplitude, together they produce >3-5x amplified pulsatile GH versus either alone (1+1>2 effect), while maintaining physiological pulsatility and minimal prolactin/cortisol impact due to Ipamorelin's selectivity.
The blend works via dual-pathway synergy. 1. DUAL PATHWAY SYNERGY: CJC-1295 No DAC – GHRH Pathway 5mg: Synthetic GHRH analog, half-life ∼30 min for natural pulsatile release, mimics GHRH → binds GHRH-Receptor on pituitary somatotrophs, activates cAMP→PKA pathway → triggers GH secretion, inhibits somatostatin release from hypothalamus → removes GH inhibition. Ipamorelin – GHRP Pathway 5mg: Selective Ghrelin/GHRP Receptor Agonist, binds GHS-R (Ghrelin Receptor) on pituitary, activates PLC→IP3/Ca2+ signaling → stimulates GH release, selective minimal effect on cortisol/prolactin. SYNERGY EFFECT Combined Activation = 1+1>2, simultaneous GHRH + GHRP stimulation → greater GH pulse amplitude & frequency → potentiated GH secretion. 2. AMPLIFIED GH PULSE & SOMATOSTATIN SUPPRESSION: Hypothalamus GHRH Release ↑ Somatostatin Release ↓ suppressed → Pituitary Gland → GH Secretion. GH Pulse: Blend vs Single Agent – CJC-1295 + Ipamorelin Blend Amplified Pulsatile Release shows >3-5x elevated GH pulse, more physiologic pulsatile pattern. 3. LIVER → IGF-1 PRODUCTION & DOWNSTREAM EFFECTS: GH → Binds GH Receptor on Hepatocytes → JAK2/STAT5 Signaling → Stimulates IGF-1 Synthesis. IGF-1 Effects: Muscle Growth & Repair ↑Protein Synthesis ↑Muscle Mass Improved Recovery, Fat Metabolism ↑Lipolysis ↓Fat Storage Improved Metabolic Use of Fat, Bone Density & Strength ↑Bone Remodeling ↑Bone Growth ↑Mineral Retention, Tissue Repair & Recovery ↑Cellular Regeneration Improved Sleep Overall Tissue Repair.
Our CJC-1295 No DAC 5mg + Ipamorelin 5mg Blend is supplied as 10mg total lyophilized powder (>99% HPLC) with COA, 5mg+5mg precisely balanced for 1:1 potency. For standard GH research, this 10mg blend is the most requested dose (also available as 2mg+2mg 4mg starter). Compared to CJC-1295 DAC (long-acting 6-8 days), this No DAC blend offers controllable daily pulses ideal for natural circadian studies. This blend belongs to Growth Hormone Peptides category, Blend sub-group, and is the anchor product for all GH stacks. Stable 24 months at -20°C. For Research Use Only.