CJC-1295 without DAC (also known as Modified GRF 1-29) is a 29-amino-acid short-acting GHRH analog with four D-amino acid substitutions to resist DPP-IV degradation but without the Drug Affinity Complex (DAC). The absence of DAC is the critical distinction: No albumin binding, half-life ∼30 minutes, rapid clearance, allows multiple controlled GH pulses per day versus CJC-1295 with DAC (half-life 6-8 days). This short-acting profile mimics endogenous GHRH pulses most closely, reducing risk of GH bleed and preserving negative feedback. It is the top trending compound for lean muscle growth and definition, GH optimization with physiological pulsatility, and research protocols stacking with Ipamorelin for synergistic GH release (GHRH + GHRP dual pathway).
CJC-1295 without DAC stimulates GH via clean pulsatile mechanism. COMPARISON: DAC vs NO DAC: CJC-1295 with DAC = GHRH Analog + DAC Group (Albumin Binding), half-life 6-8 days, prolonged GH elevation, weekly dosing. CJC-1295 No DAC = Mod GRF 1-29 (29 AA), 4 D-AA substitutions, half-life ∼30 min, short GH pulse, daily multiple dosing, more physiological. 1. GHRH RECEPTOR: CJC-1295 No DAC binds pituitary GHRHR → activates cAMP/PKA pathway → ↑GH gene transcription & release. 2. GH PULSE: Short, high-amplitude GH pulse (30-60 min peak), mimics natural sleep/exercise pulses, avoids continuous GH exposure → preserves somatostatin feedback. 3. DUAL PATHWAY SYNERGY (with Ipamorelin): Ipamorelin (GHRP-1) binds GHS-R1a ghrelin receptor in pituitary & hypothalamus, suppresses somatostatin, amplifies GH pulse magnitude when combined with GHRH analog. GHRH + GHRP → synergistic GH release > additive. 4. IGF-1 & TARGET EFFECTS: GH → Liver JAK/STAT → IGF-1 → muscle protein synthesis, collagen & bone density, lipolysis & recovery, sleep & tissue repair. Advantages: Most Natural GH Pulse, Lower Risk of GH Bleed, Ideal for Stacking, Better Control of Dosing Frequency.
Our CJC-1295 without DAC lineup is supplied as high-purity lyophilized powder (>99% HPLC). For pulsatile GH research, CJC-1295 No DAC 2mg (standard) and 5mg (value) are available. For gold-standard stacking, CJC-1295 No DAC 2mg + Ipamorelin 5mg Blend (9mg total) is the #1 seller in Growth Hormone category, plus CJC-1295 No DAC + Ipamorelin + GHRP-6 Triple Stack. CJC-1295 without DAC belongs to Growth Hormone Peptides category, short-acting subgroup, distinct from long-acting CJC-1295 with DAC. Stable 24 months at -20°C. For Research Use Only.