CJC-1295 with DAC (Drug Affinity Complex) is a 30-amino-acid long-acting GHRH (Growth Hormone Releasing Hormone) analog engineered with a lysine-linked maleimidopropionyl DAC moiety that covalently binds serum albumin after injection. This albumin binding is the defining difference versus CJC-1295 No DAC (Mod GRF 1-29): DAC extends half-life from <7 minutes (native GHRH) to ∼6-8 days, enabling once-weekly research protocols. It mimics endogenous GHRH action to stimulate pituitary GH release in a pulsatile, physiological pattern rather than continuous GH. It is the top trending compound for sustained muscle growth and protein synthesis, adult GH decline and anti-aging models, injury recovery and tissue repair, and GH/IGF-1 axis pharmacokinetic studies.
CJC-1295 with DAC works via four sequential phases. 1. CJC-1295 DAC: Albumin Binding: DAC Moiety - Lipid/Albumin Binding Site binds Albumin (>99%), protects from DPP-IV degradation, prevents rapid clearance in blood, extends half-life to ∼6-8 days (vs natural GHRH <7 min). 2. Pituitary Gland – GHRH Receptor Activation: Binds & Activates GHRHR (G-protein Coupled Receptor), triggers cAMP/PKA signaling → ↑cAMP → ↑PKA → stimulates somatotroph cells → promotes GH synthesis & release. 3. Growth Hormone (GH) Pulse: GH blood level shows pulsatile secretion over time, natural pulsatile secretion maintained, more physiological than continuous GH, promotes normal metabolic rhythms. 4. Liver → IGF-1 Production & Effects: GH binds to liver GH Receptor → JAK/STAT Pathway → IGF-1 (Insulin-like Growth Factor-1) production. IGF-1 drives muscle growth & repair, bone growth & density, metabolism • tissue repair • cellular growth. Core advantages: Long Half-Life via Albumin Binding ∼6-8 days, Sustained GH Stimulation Pulsatile not constant, Mimics Natural GHRH Action, Increased IGF-1 Levels Supports Growth & Recovery.
Our CJC-1295 with DAC lineup is supplied as high-purity lyophilized powder (>99% HPLC) with COA. For long-acting GH protocols, CJC-1295 with DAC 2mg (most requested) and CJC-1295 with DAC 5mg (value) are available. For synergistic GH pulse amplification, CJC-1295 DAC 2mg + Ipamorelin 5mg Blend (GHRH + GHRP gold standard) and CJC-1295 DAC + GHRP-6 Blend are top sellers, combining GHRH pathway with ghrelin-mimetic for amplified GH peaks. CJC-1295 with DAC belongs to Growth Hormone Peptides category, specifically the long-acting sub-group, distinct from CJC-1295 No DAC (short-acting). Stable 24 months at -20°C. For Research Use Only, not for human consumption.