Sermorelin Acetate (GRF 1-29 NH2) is a 29-amino-acid first-generation Growth Hormone Releasing Hormone analog representing the biologically active N-terminal fragment of endogenous GHRH (1-44). As the first GHRH approved by FDA (Geref), it is the prototype for all modern GHRH analogs including CJC-1295 No DAC (Mod GRF 1-29 is a tetra-substituted Sermorelin). Unlike synthetic GHRH analogs with D-amino acid substitutions, Sermorelin is identical to native GHRH 1-29 sequence, with very short half-life ∼10-12 min, producing highly physiological GH pulses closely mimicking natural nocturnal GH secretion during slow-wave sleep (peak 1-3 hours after sleep onset). It is the top trending compound for sleep quality and slow-wave sleep GH release research, age-related GH decline and recovery studies, circadian rhythm and neuroendocrine regulation, and first-line anti-aging GH protocol with maximal safety.
Sermorelin mechanism follows natural endocrine physiology. 1. MOLECULAR PROFILE: Peptide GHRH (1-29)NH2, 29-amino acid peptide, hypophysiotropic hormone, composition naturally identical to GHRH 1-29 fragment. Key Function: Stimulates growth hormone release from the anterior pituitary. Quality: Purity ≥98%, HPLC Validated, Mass Spec Confirmed. 2. SLEEP & RECOVERY MECHANISM: Hypothalamus secretes GHRH → Pituitary GH Release → Enhanced Slow-Wave Sleep → Tissue Repair & Recovery. Growth Hormone Secretion During Sleep graph: Peak GH Secretion 1-3 hours after sleep onset, natural nocturnal pulse, improved sleep quality, cellular repair & regeneration, restorative recovery. 3. LABORATORY RESEARCH & SAFETY: Analytical Methods: HPLC Analysis, Mass Spectrometry, Peptide Mapping. Storage Conditions: -20°C, Lyophilized Powder, Protect from Light & Moisture. Research Applications: Circadian Rhythm, Neuroendocrine Regulation, Recovery & Regeneration Studies. Sermorelin is ideal for sleep science research due to its strong association with slow-wave sleep GH pulses, unlike long-acting DAC versions that provide continuous elevation.
Our Sermorelin Acetate lineup is supplied as high-purity lyophilized powder (>99% HPLC) with COA. For first-generation GHRH research, Sermorelin Acetate 2mg (standard), 5mg (most requested) and 10mg (value) are available. Sermorelin belongs to Growth Hormone Peptides category, first-generation sub-group, predecessor to CJC-1295 No DAC (Mod GRF 1-29 adds 4 substitutions for longer half-life). Often stacked with Ipamorelin for dual-pathway synergy (same as CJC+IPA protocol) but with even more physiological pulse profile. Stable 24 months at -20°C. For Research Use Only, not for human consumption.